Shafiqur Rahman, PhD

Assistant Professor

Department of Pharmaceutical Sciences

College of Pharmacy

South Dakota State University

1 Administration Lane

Box 2202C

Brookings, SD 57007

Phone: 605-688-4239

Fax: 605-688-6232

Email: Shafiqur.Rahman@sdstate.edu

Education

B.Sc., Pharmacology, Dhaka University, Bangladesh

M.Sc., Pharmacology, Dhaka University, Bangladesh

Ph.D., Neuropharmacology, Memorial University of Newfoundland, Canada

Post Doctoral, Indiana University School of Medicine, Indianapolis, IN

Teaching Areas and Courses: Pharmacology and Toxicology

Pharmacology I (PHA 442)
Pharmacology II (PHA 443)
Drugs of Abuse and Addiction (PHA 752)
Advanced Concepts in Pharmacology (PHA 840)
Topics in Advanced Pharmacology (PHA 845)

Research Interests

Neuropharmacology

Drug and alcohol Addiction

Drug Discovery and Development

Ethnopharmacology

Research Grants/Support

Rahman, S (Principal Investigator) Preclinical drug development for alcoholism and

neurological diseases. South Dakota Governor's 2010 Individual Research Grant.

 
Rahman, S (Co-Investigator) Synthesis and biological evaluation of new compounds as potential anti-anxiety and antidepressant agents. SDSU Research Scholarship Fund. Fahmy, H (P.I.).
 
Rahman, S (Principal Investigator). Development of nicotinic receptor ligands in ethanol dependence. SDSU Research Scholarship Fund.

Rahman, S. (Co-Investigator). Hippocampal neurotoxicity induced by ethanol withdrawal. National Institute on Alcoholism and Alcohol Abuse/NIH. Prendergast, M. (P.I.), (pending).

Rahman, S. (Co-Principal Investigator). Cholinergic and opiate mechanism in drug reinforcement. National Institute on Drug Abuse/NIH. Corrigall, W.A. (P.I.).

Rahman, S. (Principal Investigator). Dopamine and non-dopamine mechanisms of nicotine addiction. University of Toronto Medical Research Foundation, Canada.

Rahman, S. (Principal Investigator). Neurochemical mechanisms in nicotine addiction: Microdialysis study. CAMH Psychiatry Research Foundation, Canada.

Rahman, S. (Co-Investigator). Transdisciplinary smoking and nicotine dependence research in special populations. Canadian Institute of Health Research, Canada. Selby, P. (P.I.).

Selected Publications (from 52 peer reviewed research papers in national and international journals):

Rahman, S., Zhang Z, Crooks P. A., Dwoskin L. P., Bardo M. T. Region-specific effects of N,N’-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB) on nicotine-induced increase in extracellular dopamine in vivo. British J. Pharmacol., 153, 792–804 (2008). Epub Dec 3, 2007.

Rahman, S., Bardo M.T., Environmental enrichment increases amphetamine-induced glutamate neurotransmission in the nucleus accumbens: a neurochemical study. Brain Res., 1197, 40-46 (2008)

Rahman, S., Neugebauer, N.M., Zhang, Z., Crooks, P.A., Dwoskin, L.P., Bardo, M.T. The effects of novel N,N-dodecane-1,12-diyl-bis-3-picolinium dibromide on acute and repeated nicotine-induced increases in extracellular dopamine response in rat nucleus accumbens. Neuropharmacology, 52, 755-763 (2007). Epub 2006 Nov 9.

Rahman, S., Zhang, J., Engleman, E., Corrigall, W.A. Neuroadaptive changes in mesolimbic dopamine system after chronic nicotine self-administration: A microdialysis study. Neuroscience, 129, 415-424 (2004).

Rahman, S., Zhang, J., Corrigall, W.A. Local perfusion of nicotine differentially modulates somatodendritic dopamine release in the rat ventral tegmental area after nicotine preexposure. Neurochemical  Res., 29, 1687-1693 (2004).

Rahman, S., Zhang, J., Corrigall, W.A. Effect of nicotine exposure on sulpiride-induced dopamine release in the nucleus accumbens. Eur. J. Pharmacol., 494, 31-34 (2004).

Rahman, S., Zhang, J., Corrigall, W.A. Effects of acute and chronic nicotine on somatodendritic dopamine release of the rat ventral tegmental area in vivo microdialysis study. Neuroscience Lett., 348, 61-64 (2003).

Rahman, S., McBride, W.J. Involvement of GABA and cholinergic receptors in the nucleusaccumbens on feedback control of somatodendritic dopamine release in the VTA.  J. Neurochem., 80, 646-654 (2002).

Alam, M.K., Rahman, S., Chowdhury, F.A. Antiepileptic activity of five indigenous medicinal plants. Bangladesh J. Life Sci., 14, 83-86 (2002).

Alam, M.K., Rahman, S., Chowdhury, F.A. Antidepressant activity of some medicinal plants of Bangladesh. Bangladesh J. Life Sci., 14, 55-59 (2002).

Rahman, S., McBride, W.J. Dopamine D1-D2 receptor interaction within the nucleus accumbens mediates long-loop negative feedback to the VTA. J Neurochem., 77, 1248-1255 (2001).

Rahman, S., Hasnat, A., Hasan, C.M., Rashid, M.A., Ilias, M. Pharmacological evaluation of traditionally used medicinal plants of Bangladesh. Pharmaceutical Biology. 39, 1-6 (2001).

Rahman, S., Engleman, E., Simon, J., and McBride, W.J. Negative interaction of D2 receptorantagonist and GBR-12909 and GBR 12935 dopamine uptake inhibitors in the nucleus accumbens. Eur J Pharmacol., 414, 37-44 (2001).

Rahman, S., McBride, W.J. Feedback control of mesolimbic somatodendritic dopamine release in rat brain. J. Neurochem., 74, 684-692 (2000).

Rahman, S., Li, P.P., Kish, S.J., Young, L.T., Kofman, O. Warsh, J.J. Reduced [³H]cAMP binding in bipolar affective disorder. J. Neurochem., 68, 297-304 (1997).

Rahman, S., Choudhury, S.A.R. Glutamate receptors in the central nervous system: A novel therapeutic strategy for cerebral ischemia. Bangladesh J. Physiol. Pharmacol., 13, 58-61 (1997).

Rahman, S., Neuman, R.S. Characterization of metabotropic glutamate receptor mediated facilitation of N-methyl-D-aspartate depolarization of neocortical neurons. Br. J. Pharmacol., 117, 675-683 (1996).

Rahman, S., Neuman, R.S. Calcimycin, cyclopiazonic acid, and thapsigargin mimic 5-hydroxytryptamine in facilitating N-methyl-D-aspartate depolarization of cortical neurons. Br. J. Pharmacol., 119, 877-884 (1996).

Rahman, S., McLean, J., Darby-King, A., Paterno, G., Reynolds, J., Neuman, R.S. Loss of cortical serotonin 5-HT_2A signal transduction in senescent rats: Reversal following  inhibition of protein kinase C. Neuroscience, 66, 891-901 (1995).

Neuman, R.S., Rahman, S. Calcium mobilizing compounds mimic 5-HT induced facilitation of N-methyl-D-aspartate depolarization. Behav. Brain. Res., 73, 273-275 (1995).

Rahman, S., Neuman, R.S. Multiple mechanisms of serotonin (5-HT_2A) receptor desensitization. Eur. J. Pharmacol., 238, 173-180 (1993).

Rahman, S., Neuman, R.S. Myo-inositol reduces serotonin (5-HT_2A) receptor induced homologous and heterologous desensitization. Brain Res., 631, 349-351 (1993).

Rahman, S., Neuman, R.S. Activation of 5-HT_2A receptors facilitates depolarization of neocortical neurons by N-methyl-D-aspartate. Eur. J. Pharmacol., 231, 347-354 (1993).

Neuman, R.S., Rahman, S. Activation of serotonin receptors enhances depolarization of neocortical neurons by NMDA. Br. J. Pharmacol., 107, 11 (1992).

Conference/Meeting Abstracts

Over 25 presentations in national and international meetings

Professional Memberships

American Society of Pharmacology and Experimental Therapeutics

American Association of Pharmaceutical Scientists

American Association of Colleges of Pharmacy

Society for Neuroscience

International Brain Research Organization, Paris, France

Rho Chi Honorary Society 

Journal Editorial Board Member

CNS and Neurological Disorders-Drug Targets

Drug Development and Therapeutics

Reviewer for Scientific Journals

Nicotine and Tobacco Research

European Journal of Pharmacology

Neurochemical Research

Brain Research

Neuroscience Letters

Synapse

Physiology and Behaviour

Awards and Honours

Biographical profile included in Marquis Who’s Who in America (2007), USA

Biographical sketch for leading scientist included in International Biographical Centre, Cambridge, London (2007), UK

Biographical profile included in Marquis Who’s Who in Science and Engineering (2000), USA

Postdoctoral Research Fellowship, Indiana University, Indianapolis, IN, USA

Clarke Foundation Fellowship, University of Toronto, Canada

Memorial University of Newfoundland Fellowship, Canada

Chancellor’s Award, Dhaka University, Bangladesh