Assistant Professor
Department of Pharmaceutical Sciences
South Dakota State University
College of Pharmacy
Box 2202C
Brookings SD 57007-0099
Phone: (605) 688-4745
FAX: (605) 688-5993
E-Mail: omathanu.perumal@sdstate.edu
Post Doctoral Research Fellow, School of Medicine, Wayne State University, USA
Post Doctoral Research Scholar, Department of Pharmaceutical Sciences, University of Kentucky, USA
Ph.D. (Pharmaceutics), National Institute of Pharmaceutical Education & Research (NIPER), India
M.Pharm (Pharmaceutics), Birla Institute of Technology, India
B.Pharm, Dr. M.G.R. Medical University, India
Teaching Areas and Courses: Pharmaceutics Drug Delivery and Pharmacokinetics
Undergraduate Courses:
Pharmaceutics I (PHA 331)
Biopharmaceutics and Pharmacokinetics (PHA 415)
Pharmaceutics II (PHA 332)
Graduate Courses:
Advanced Pharmaceutics (PHA 859)
Topics in Pharmaceutics (PHA 865)
Techniques in Pharmaceutical Sciences (PHA 846)
Seminar (PHA 890)
Research Interests:
The central tenets of our research is to understand the molecular basis of improving the 'deliverability' of drugs at the interface of chemical and biological sciences. This knowledge is used to design novel delivery systems to address drug permeability and solubility issues with specific focus on the following:
1. Enhance Transdermal Delivery of Small and Large Molecules.
2. Design and Evaluation of Novel Nanostructured Delivery Vehicles.
3. Transcutaneous Vaccine Delivery Systems.
4. Protein and DNA Delivery Systems.
5. Design of Intracellular Drug Delivery Vehicles.
6. Preformulation and Solid-state Pharmaceutics.
Active Projects:
1. Dendrimers as Topical/Transdermal Drug Delivery Vehicles
2. Transcutaneous Delivery of Gene Based Medicines
3. Zein nanoparticles for Drug Delivery Applications
4. Transcutanoues Vaccine Delivery
5. Dendrimers as Intracellular Drug Delivery Vehicles
Graduate Students
Vamsi Venuganti
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Satheesh Podaralla
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Preety Sahdev
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Publications and Presentations:
Over 80 in peer-reviewed journals and conferences.
Book Chapters:
1. Kannan, RM., Perumal, O., Kannan, S. Cellular Interactions of Nano Drug Delivery Systems. Force Microscopy: Applications in Biology and Medicine. Edited by Bhanu P. Jena and Johann Karl H. Hoerber. John Wiley and Sons, Inc., July 2006.
2. Kannan, RM., Perumal, O., Kannan, S. Dendrimers and Hyperbranched Polymers for Drug Delivery. Biomedical Applications of Nanotechnology. Edited by V. Labhasetwar and D.L. Leslie-Pelecky. John Wiley and Sons, Inc., July 2006.
3. Perumal, O., Podaralla, SK. Preformulation. Pharmaceutical Manufacturing Handbook. Edited by Shayne Gad. John Wiley and Sons, Inc. 933-975, 2008.
Review Articles:
1. Varma, MVS., Perumal, O., Panchagnula, R. Functional Role of P-glycoprotein in Limiting Peroral Drug Absorption: Optimizing Drug Delivery. Curr Opin Chem Biol. 10:1-7 (2006).
2. Varma, MS., Khandavilli, S., Ashokraj, Y., Jain, A., Dhanikula, A., Sood, A., Thomas, N.S., Pillai, O., Sharma, P., Gandhi, R., Agrawal, S., Nair, V., Panchagnula, R.: Biopharmaceutic classification system: A scientific framework for pharmacokinetic optimization in drug research. Curr. Drug Metabol. 5: 375-388 (2004).
3. Pillai, O., Panchagnula, R.: Insulin therapies- past, present and future. Drug Discov. Today. 20: 1056-1061 (2001).
4. Pillai, O., Nair, V., Jain A., Narisetty ST., Panchagnula, R.: Non-invasive transdermal delivery of peptides and proteins. Drugs Fut. 26: 779-791 (2001).
5. Pillai, O., Dhanikula, AB., Panchagnula, R.: Drug Delivery- An Odyssey of 100 years. Curr. Opin. Chem. Biol. 5: 439-446 (2001).
6. Pillai, O., Panchagnula, R.: Polymers in drug delivery. Curr. Opin. Chem. Biol. 5: 447-450 (2001).
7. Panchagnula, R., Pillai, O., Nair, V., Poduri, R.: Transdermal Iontophoresis revisited. Curr. Opin. Chem. Biol. 4: 468-473 (2000).
8. Panchagnula, R., Jain, AK., Pillai, O., Jaiswal, JK.: Nicotine Transdermal Systems: Pharmaceutical and Clinical aspects. Methods Find. Exp. Clin. Pharmacol. 22: 299-308 (2000).
9. Nair, V, Pillai, O., Poduri, R., Panchagnula, R.: Transdermal Iontophoresis. Part I. Basic Principles and Considerations. Methods Find. Exp. Clin. Pharmacol. 21: 139-151 (1999).
10. Pillai, O., Nair, V., Poduri, R., Panchagnula, R.: Transdermal Iontophoresis. Part II. Peptide and Protein delivery. Methods Find. Exp. Clin. Pharmacol. 21: 229-240 (1999).
Research Papers:
Selected from 38 peer reviewed papers.
Transdermal Drug Delivery:
1. Venuganti, V., Perumal, O: Effect of Dendrimer charge, generation and concentration on Skin Permeation of 5-Fluorouracil. J. Pharm. Sci (in press)
2. Venuganti, V., Perumal, O: Effect of Poly(amidoamine) (PAMAM) Dendrimer on Skin Permeation of 5-Fluorouracil. Int. J. Pharm. 361:230-238 (2008).
3. Pillai, O., Panchagnula, R.: Transdermal iontophoresis of insulin VI: Influence of pretreatment with fatty acids on rat skin. Skin Pharmacol. Appl. Skin Phyisol. 17: 289-297 (2004).
4. Pillai, O., Kumar N., Dey CS., Panchagnula, R.: Transdermal iontophoresis of insulin III: Influence of electronic parameters. Methods Find. Exp. Clin. Pharmacol. 26: 399-408 (2004).
5. Pillai, O., Hamad, M., Crooks, PA, Stinchcomb, AL.: Physicochemical evaluation, in-vitro human skin diffusion and concurrent biotransformation of 3-O-alkyl carbonate prodrugs of naltrexone. Pharm. Res. 21: 1146-1152 (2004).
6. Pillai, O., Nair V., Panchagnula, R.: Transdermal iontophoresis of insulin IV: influence of chemical enhancers. Int. J. Pharm. 269: 109-120 (2004).
7. Pillai, O., Kumar N., Dey CS., Borkute, SD., Sivaprasad, N., Panchagnula, R.: Transdermal iontophoresis of insulin I: A study on the issues associated with the use of platinum electrodes. J. Pharm. Pharmacol. 55: 1505-1513 (2003).
8. Pillai, O., Panchagnula, R.: Transdermal delivery of insulin from poloxamer 407 gel: Ex-vivo and in-vivo studies in rat using iontophoresis and chemical enhancers. J. Control. Release 89: 127-140 (2003).
9. Pillai, O., Panchagnula, R.: Transdermal iontophoresis of insulin V: Effect of terpenes. J. Control. Release 88: 287-296 (2003).
10. Pillai, O., Borkute, SD., Sivaprasad, N., Panchagnula, R.: Transdermal Iontophoresis of insulin II: Physicochemical considerations. Int. J. Pharm. 254: 271-280 (2003).
Nanostructured Delivery Vehicles:
1. Perumal, O., Inagapolla, R., Kannan, RM., Kannan, S: Surface functionality influences cellular trafficking of dendritic nanomaterials Biomaterials 29:3469-3476 (2008).
2. Kolhe, P., Khandare, J., Pillai, O., Kannan, S., Lieh-Lai, M., Kannan, RM. Design and biological evaluation of dendritic nanodevices for enhanced cellular delivery. Biomaterials. 27:660-669 (2006).
3. Khandare, J., Kolhe, P., Pillai, O. Kannan, S., Lieh-Lai, M., Kannan, RM. Synthesis, cellular transport and activity of dendrimer-methylprednisolone conjugate. Bioconjugate Chem. 16:330-337 (2005).
4. Kannan, S, Perumal, O., Khandare, Lieh-Lai, M., Kannan, RM., Khandare, J. Enhanced delivery of anti-inflammatory drugs using novel dendritic nanopolymers. Critical Care Med. 32(12) suppl: pA142 (2004).
5. Kolhe, P., Khandare, J., Pillai, O., Kannan, S., Lieh-Lai, M., Kannan, RM. Hyperbranched polymer-drug conjugates with high drug payload for enhanced cellular delivery. Pharm. Res. 21: 2185-2195 (2004).
Preformulation and Solid State Pharmaceutics:
1. Panchagnula, R., Bapurao. T., Raj, YA., Pillai, O. Mefenamic acid: A new polymorph or crystal defect. Pharm Technol (Europe). 18.10 Oct p41 (6)(2006).
2. Agrawal, S., Ashokraj, Y., Bharatam, PV., Pillai, O., Panchagnula, R. Solid-state characterization of rifampicin samples and its biopharmaceutic relevance. Eur J Pharm Sci. 22: 127-144 (2004).
3. Panchagnula, R., Prakash, S., Pillai, O., Agrawal, S, Raj, YA. Solid state characterization of mefenamic acid. J Pharm Sci. 93: 1019-1029 (2004).
4. Gandhi, R., Pillai, O., Thilagavathi, R., Gopalakrishnan, B., Kaul, CL., Panchagnula, R.: Characterization of azithromycin hydrates. Eur J Pharm Sci. 16: 175-184 (2002).
Provisional Patent
Perumal, O., Podaralla, S., Kaushik, R. Non-immunogenic protein nanoparticles. Provisional US Patent (filed)
Conference Presentations/Invited Talk:
More than 40 in various national and international conferences.
Media
http://www.brookingsregister.com/V2_news_articles.php?heading=0&story_id=2478&page=76 
/SDSU/NewsDetail45702.cfm?ID=46,6565
http://inpharma.adisonline.com/pt/re/inp/abstract.00128413-200816490-00021.htm;jsessionid=LJcLXphhhqpJ1Slw9BVpxnYP7TMpQBP2Tjh0gwKvpThp2SkCHTW4!609209752!181195628!8091!-1
http://sdsu.imodules.com/s/357/viewcontent.aspx?sid=357&gid=1&pgid=262&cid=1251&ecid=1251&crid=0&calpgid=889&calcid=1064
http://www.ethanolproducer.com/article.jsp?article_id=4476
http://www.news-medical.net/?id=40374
http://www.medicalnewstoday.com/articles/116403.php
http://biomassrules.com/BurningBioNews/?cat=37
http://www.sdbor.edu/administration/research/highlights/SDSUResearch.htm
Professional Activities/Memberships:
Journal Editorship
Associate Editor, Journal of Biomedical Nanotechnology
Journal Reviewer
Journal of Controlled Release
Journal of Phamaceutical Sciences
International Journal of Pharmaceutics
Journal of Investigative Dermatology
British Journal of Pharmacology
Biomacromolecules
Journal of Biomedical Nanotechnology
European Journal of Pharmaceutics and Biopharmaceutics
Current Drug Delivery
AAPS Journal
Grant Reviewer
Center for Innovation, Canada
Nova Scotia Health Research Foundation, Canada
Thesis Evaluator
Ph.D. Thesis Examiner, All India Institute of Medical Services (AIIMS), India; Dr. M.G. R. Medical University. India
Professional Memberships
American Association of Pharmaceutical Scientists
Controlled Release Society
American Association of Colleges of Pharmacy
Sigma Xi Scientific Research Society
Rho Chi Honor Society
Awards and Honors:
Dr. Patricia Wexler Resarch Grant Award from Skin Cancer Foundation. 2008
Biographical profile included in Marquis Who's Who in Science and Engineering (2005), Who's Who in America (2006), Who's Who in the World (2006), and Who's Who of Emerging Leaders (2007).
Biographical sketch included in Manchester Who’s Who (2005).
Biographical sketch included in Madison Who’s Who of Professionals and Executives (2005).
Recipient of AAPS travel fellowship for AAPS-PDD conference (2004).
Senior Research Fellowship from the Department of Science & Technology, India (1998-2002).
Senior Research Fellowship from the University Grants Commission, India (1995-1997).
Administrative Responsibilities:
Member, Organizing Committee, Eastern South Dakota Science and Engineering Fair at the University
College Representative Sewery Colloguim Committee
Member, Graduate Studies and Research Committee, College of Pharmacy
Member, Strategic Planning Committee, College of Pharmacy
Department of Pharmaceutical Sciences Seminar Coordinator
Faculty Advisor, Indian Students Association, SDSU
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