Department of Pharmaceutical Sciences
South Dakota State University
College of Pharmacy - Box 2202C
Brookings, SD 57007
Phone: (605) 688-4236
Fax: (605) 688-5993
E-Mail: marek.malecki@sdstate.edu

GRADUATE EDUCATION
Ph.D. from Polish Academy of Sciences, Warsaw, Poland
M.D. from Medical Academy, Poznan, Poland 
Fellowship at Rigshospitalet, Copenhagen, Denmark

POSTDOCTORAL AND PROFESSIONAL TRAINING
Austrian Academy of Sciences Research Fellow, Inst. of Mol. Biol., Salzburg, Austria
European Molecular Biology Organization Research Fellow, Med. School, Utrecht, Holland
European Molecular Biology Organization Research Fellow, ETH, Zurich, Switzerland
European Molecular Biology Organization Research Fellow, Inst. of Mol. Biol., Austria
European Molecular Biology Organization Research Fellow, Med. School, Utrecht, Holland

Teaching Areas and Courses: Pharmacology and Toxicology:
Pharmacology I  (PHA 442)
Pharmacology II (PHA 443)
Advanced Pharmacology (PHA 740)

Research Areas:
Cancer Vaccination, Detection, Diagnosis, and Gene Therapy.

Discipline:
Pharmaceutical biotechnology

Publications:

Selected Books and Book Chapters

Malecki M. & Roomans G. (eds.) 1996. Science of Specimen Preparation for Microscopy and Microanalysis.
SM International Press, Chicago, IL, USA (introduced as a handbook for fellows by American
Association of Pathologists).
Malecki M. 1996. Preparation of plasmid DNA in transfection complexes for spectroscopic imaging. In: Marek
Malecki and Godfried Roomans (eds.): Specimen Preparation for Microscopy and Microanalysis. SM
International Press, Chicago, IL : 1-16.
Malecki M., Dahlke J., Haig M., & Wohlwend L. 1998. Photoconversion and metal enhancement of probes for
electron spectroscopic imaging. In: Calderon Benavides H. A. & Yacaman M. J. (eds.) Electron
Microscopy, Cancun, Mexic 1, 709-720.

Selected Recent Peer-Reviewed Articles
Malecki M. et al. 2001. Molecular immunolabeling with bioengineered recombinant scFv antibodies.
Proceedings of the National Academy of Sciences USA (on line December 2001) 99: 213.
Malecki M.2002. Molecular bioengineering of multifuctional markers for positron emission tomography
(PET), Gammascintigraphy (GS), and magnetic resonance imaging (MRI) Microsc & Microanal
1:97.
Malecki M, Hsu A, Truong L, Nowak M, L’Vanne K, Sundaram S, Watkins J, Grist T. Bioengineering of recombinant
antibody-chelate fusion proteins for molecular imaging and image guided therapy. Antibody Bioengineering 2003, 1, 69.
Malecki M. & Greaser M. 2003. Bioengineering of Antibodies. Microsc & Microan 2, 1192.
Malecki M. et al. 2007. Nuclear routing network guides targeted transport of transgenes.
Proceedings of the National Academy of Sciences USA – submitted.
Malecki M, Konat G, Hsu A, L’Alhambra D, Malecki R, Pietruszkiewicz J. Nanosurgery on cancer. ESSO 2006, 1, 8
Malecki M. et al. 2007. “Nanoengineered antibodies against embryonal carcinoma’s SSEA-3, SSEA-4,
TRA-1-60, and TRA-1-81 demonstrate presence of pluripotent cells in situ, in bone marrow” ESSO Proceedings 2,13

Selected Recent Invited Presentations at International and National Meetings
Antigen Presentation and Phage Display Conference 2003, Boston, “Production Of Anti-Transferrin-Receptor
Antibodies”.
Antibody Engineering 2003, San Diego, “Bioengineering of recombinant, polyvalent, heterospecific scFv antibodies as fusion proteins”.
Society for Molecular Imaging 2003, San Francisco, In vivo Immunohistochemistry Using Single Chain
Variable Fragment Recombinant Antibodies”.
Society for Molecular Imaging 2003, San Francisco, “Anti-Transferrin-Receptor Single Chain Variable
Fragment Recombinant Antibodies Bioengineered For Molecular Imaging”
M&M 2004, Savannah, “Molecular Labels Of Different Elemental Composition”.
European Society for Oncological Surgery Conference 2006. “Nanosurgery of cancer with the aid of nanoengineered, intracellular antibodies”.
European Society for Oncological Surgery Conference 2006, “Nanoengineered antibodies against embryonal carcinoma’s SSEA-3, SSEA-4, TRA-1-60, and
TRA-1-81 demonstrate presence of pluripotent cells in situ, in healthy human bone marrow”.
NCI, AACR Symposium 2006 “Molecular Targets and Cancer Therapeutics” “Pluripotent stem cells are present in situ, in healthy human bone marrow”.
NCI, AACR Symposium 2006 “Molecular Targets and Cancer Therapeutics” “Suicide gene therapy of cancer”.
SD Academy of Sciences Annual Meeting 2007. "Cancer cell suicide induced by interesectiong signaling pathways".

Active Research Projects:
Cancer suicide gene therapy 

Professional Memberships:
Rho Chi Honorary Society
Academy of Sciences

EDITOR FOR PEER-REVIEWED SCIENTIFIC JOURNALS
Editor: SMI 1992-present
Reviewer:  Journal of Structural Biology, Brain Research, Journal of Immunological Methods, Journal of Neuroscience, Neuroscience, Scanning, Society for Molecular Imaging

REVIEWER FOR GRANT FUNDING FEDERAL AGENCIES
NSF: 1992-present
NIH: 1995-present