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Home Page > Academics > College Of Pharmacy > Department of Pharmaceutical Sciences > Faculty/Staff > Hesham Fahmy


Hesham Fahmy

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Associate Professor of Pharmaceutical Sciences



South Dakota State University

College of Pharmacy

Box 2202C

Brookings SD 57007-0099

Phone: (605) 688-4243

FAX: (605) 688-5993

E-Mail: Hesham.Fahmy@sdstate.edu



B.S. Pharmacy, University of Alexandria

M.S. Pharmaceutical Chemistry, University of Alexandria

Ph.D. Pharmaceutical Chemistry, University of Alexandria

Post-Doctoral: University of Texas

Research Scientist: University of Glasgow, Scotland and the University of Mississippi



Teaching Areas and Courses: Medicinal Chemistry

Medicinal Chemistry I (PHA 340)

Medicinal Chemistry II (PHA 341)

Advanced Medicinal Chemistry (PHA 720)

Topics in Medicinal Chemistry (PHA 725)



Academic/Research Areas:

Novel chemopreventaive agents

Corticotropine Releasing Factor (CRF) receptor antagonists as new anti-anxiety agents

Antifungal Agents




Awards and Honors:

Reviewer for Heteroatom Chemistry

Reviewer for Chemical Papers


Reviewer for Archiv der Pharmazie


Reviewer for European Journal of Medicinal Chemistry


Reviewer for Bio-organic and Medicinal Chemistry Letters


Reviewer for the US Civilian Research and Development Foundation (CRDF)




Patents:

2 USA/International Patents:



Zjawiony, J. K., Fahmy, H., Katsuyama, I., Khalifa, S., Konoshima, T.: Cembranoids of Chemopreventive Activity. PCT Int. Appl. WO 2003095404, A1 20031120 (2003), C.A. 139, 381637 (2003).



Zjawiony, Jordan; Fahmy, Hesham; Stewart, Jeremy; Roth, Bryan. Salvinorin derivatives with selective k-opioid receptor affinity. PCT Int. Appl. WO 2006012643, A2 20060202 (2006), C.A. 144, 164284 (2006).



Publications:

32 publications in national and international journals


Faidallah, H.M., Al-Saadi, M. S., Rostom, S. A. F. and Fahmy, H. Synthesis of some sulfonamides, disubstituted sulfonylureas or thioureas and some structurally related variants. A class of promising antitumor agents: Medicinal Chemistry Research. (2007) Accepted for publication and appeared on the Journal Website



Kundoor, V.,Zhang, X., , Khalifa, S., Bommareddy, A., Khalifa, S., Fahmy, H., Dwivedi, C. Chemopreventive effects of sarcotriol on ultraviolet B-induced skin tumor developments on SKH-1 hairless mice. Marine Drugs, 5, 197-207 (2007)



Zhang, X., Schrader, D., Kundoor, V., Khalifa, S., Zeman, D., Fahmy, H., Dwivedi, C. Effects of Sarcophine-diol in Human Epidermoid Carcinoma A431 Cells and its Possible Mechanism of Action. Cancer Letters, 253, 53-59 (2007).



Rida, S., El-Hawash, S., Fahmy, H., Hazza, A., El-Meligy, M. Synthesis of Novel Benzofuran and Related Benzimidazole Derivative for Evaluation of in vitro Anti-HIV-1, Anticancer, and Antimicrobial Activities. Arch Pharm Res, 29(10), 826-833 (2006).



Kundoor, V., Zhang, X., Khalifa, S., Fahmy, H., Dwivedi, C. A Possible Mechanism of Action of the Chemopreventive Effects of Sarcotriol on Skin Tumor Development in CD-1 Mice. Marine Drugs, 4, 274-285
(2006).



Fahmy, H., Zjawiony, J., Konoshima, K., Tokuda, H., Khan, S., Khalifa, S. Potent Skin Cancer Chemopreventive Activity of Some Novel Semi-synthetic Cembranoids from Marine Sources. Marine Drugs, 4, 28-36 (2006).






Stewart, J., Fahmy, H., Roth, B., Yan, F., Zjawiony, J. Bioisosteric Modification of Salvinorin A, a Potent and Selective Kappa-Opoid Receptor Agonist. Arzneim Forsch./Drug Res. 56(4), 269-275 (2006).



Rida, S., El-Hawash, S., Fahmy, H., Hazza, A., El-Meligy, M. Synthesis and in vitro Evaluation of Some Novel Benzofuran Derivatives as Potential Anti-HIV-1, Anticancer and Antimicrobial Agents. Acrch Pharm Res., 29(1), 16-25 (2006).



Fahmy, H., Khalifa, S. I., Konoshima, T., Zjawiony, J. K.: An Improved Synthesis of 7,8-Epoxy1,3,11-cembratriene-15R(a), 16-diol, A Cembranoid of Marine Origin With a Potent Cancer Chemopreventive Activity. Marine Drugs, 1, 1-7 (2004).



Stewart, J. Katsuyama, I., Fahmy, H., Fronczek, F. R., Zjawiony, J. K.: A Direct Synthesis of 3,5-Dibromo-O-methyl-L-tyrosine. Synthetic Communications 34(3), 531-539 (2004).



Bekhit, A. A., Fahmy, H. T., Rostom, S. A., Baraka, A.: Design and Synthesis of Some Substituted 1H-pyrazolyl thiazolo[4,5-d]pyrimidines as Anti-inflammatory - Antimicrobial Agents. Eur. J. Med. Chem. 38(1), 27-36 (2003).



Rostom, S. A., Fahmy, H. T., Saudi, M. N.: Synthesis and in-vitro Anti-HIV Screening of Certain 2-(benzoxazol-2-ylamino)-3H-4-oxopyrimidines. Scientia Phatmaceutica, 71(2), 57-74 (2003).



Saudi, M. N., Rostom, S. F., Fahmy, H. T., El Ashmaway, I. M.: Synthesis of 2-(4-Biphenylyl)-quinoline-4-carboxylate and carboxamide Analogs. New Human Neurokinin-3 (hNM-3) Receptor Antagonists. Arch. Pham. Pharm. Med. Chem. (Weinheim) 336(3), 165-174 (2003).



Fahmy, H. T., Rostom, S. A., Saudi, M. N., Zjawiony, J. K., Robins, D. J.: Synthesis and in-vitro Evaluation of The Anticancer Activity of Novel Fluorinated Thiazolo[4,5-d]pyrimidines. Arch. Pham. Pharm. Med. Chem. (Weinheim) 336(4-5), 216-225 (2003).



Bekhit, A., Fahmy, H. T.: Design and Synthesis of Some Substituted 1H-Pyrazolyl-Oxazolidines or 1H-Pyrazolyl-Thiazolidines as Anti-inflammatory-Antimicrobial agents. Arch. Pham. Pharm. Med. Chem. (Weinheim) 336(2), 111-118 (2003).



Mahindaratne, M., Fahmy, H., Garcia, J. A., Negrete, G. R.: Synthesese of cis- and trans-7-chloro-7,8,9,10-tetrahydrobenzo[a]pyren-8-ol: Remarkable Solvent Effect on Epoxide Hydrochlorination Diastereoselectivity. Synthetic Commuincation, 33(8), 1391-1398 (2003).



Fahmy, H., Zjawiony, J. K., Khalifa, S., Fronczek, F. R.: A Semi-synthetic Analog of The Cembranoid Sarcophine. Acta Cryst. C59, 85-87 (2003).



Katsuyama, I., Fahmy, H., Zjawiony, J. K., Zjaiowny, J. K., Khalifa, S. I., Kilada, R. W, Konoshima, T. , Takasaki, M. and Tokuda, H..: Semisynthesis of New Sarcophine Derivatives With Chemopreventive Activity. J. Natural Products 65, 1808-1814 (2002).



Fahmy, H. T., Bekhit, A. A.: Synthesis of Some New Bis-thiazoles As Possible Anticancer Agents. Pharmazie, 57(12), 800-803 (2002).



Fahmy, H. T., Rostom, S. A., Bekhit, A. A.: Synthesis and Antitumor Evaluation of New Polysubstituted Thiazole and Derived Thiazolo[4,5-d]pyrimidine Systems. Arch. Pharm. Pharm. Med. Chem. (Weinheim) 335(5),
213-222 (2002).



Fahmy, H. T.: Synthesis of Some New Triazoles as Potential Antifungal Agents. Bollitino Chemico Pharmaceutico 140, 423-427 (2001).



Fahmy, H. T.: Synthesis and Antimicrobial Screening of Some Novel Thiazoles, Dithiazoles, and Thiazolylpyridines. Pharmazie 52(10), 750-753 (1997).



Habib, N. S., Rida, S. M., Badawey, E. A., Fahmy, H. T., Ghozlan, H. A.: Synthesis and Antimicrobial Activity of Rhodanine Derivatives. Eur. J. Med. Chem. 32(9), 759-762 (1997).



Habibi, N. S., Rida, S. M., Badawey, E. A., Fahmy, H. T., Ghozlan, H. A.: Synthesis and Biological Investigations of Novel Thiazolyl-benzimidazoles and Benzimidazolyl-thiazlo[4,5-d]pyrimidines. Pharmazie 52(5), 346-350
(1997).



Habib, N. S., Rida, S. M., Badawey, E. A., Fahmy, H. T., Ghozlan, H. A.: Synthesis of Novel Thiazolo[4,5-d]pyrimidines Derivatives for Antimicrobial, Anti-HIV, and Anticancer Investigation. Pharmazie 51(12), 927-931
(1996).



Habib, N. S., Rida, S. M., Badawey, E. A., Fahmy, H.T.: Condensed Thiazoles:I. Synthesis of 5,7-Disubstituted Thiazolo[4,5-d]pyrimidines as Possible Anti-HIV, Anticancer, and Antimicrobial Agents. Monatsh Chemie 127(11), 1203-1207
(1996).



Rida, S. M., Habib, N. S., Badawey, E. A., Fahmy, H. T.: Condensed Thiazoles: II. Synthesis of 7-Substituted Thiazolo[4,5-d]pyrimidines as Possible Anti-HIV, Anticancer, and Antimicrobial Agents. Monatsh Chemie 127(11), 1209-1214
(1996).



Mahran, M. A., El-Sayed, O. A., Fahmy, H. T., Ashour, F. A.: Synthesis of Some Novel Perhydrotriazepine-3,6-diones of Potential Antifungal Activity. Alex. J. Pharm. Sci. 10(2), 133-135 (1996).



Rida, S. M., Habib, N. S., Badawey, E. A., Fahmy, H. T., Ghozlan, H. A.: Synthesis and Biological Investigations of Some New Thiazolyl-benzimidazoles and Benzimidazolyl-thiazolo[3,2-a]pyridines. Arch. Pharm. (Weinheim) 328(4), 325-328 (1995).



Badawey, E. A., Rida, S. M., Hazza, A. A., Fahmy, H. T., Gohar, Y.M.: Potential Antimicrobials I. Synthesis and Structure-Activity Studies of Some New Thiazolo[4,5-d]pyrimidine Derivatives. Eur. J. Med. Chem. 28(2), 91-96
(1993).



Badawey, E. A., Rida, S. M., Hazza, A. A., Fahmy, H. T., Gohar, Y.M.: Potential Antimicrobials II. Synthesis and In-Vitro Anti-Microbial Evaluation of Some New Thiazolo[4,5-d]pyrimidine Derivatives. Eur. J. Med. Chem. 28(2), 97-101 (1993).



Badawey, Hazza, A. A., E. A., Rida, S. M., Fahmy, H. T.: Assesment of Anti-HIV Activity of Some Benzimidazolyl-thiazoles. Arch. Pharm. (Weinheim) 325(9), 565-567 (1992).




Grants:



Grants from The Government of Egypt to support exchange students: $150,000.00 (12/2005-12/2007)

Governor's 2010 Individual Research Seed Grant. "Development of potent skin cancer chemopreventive agents from marine sources, $43,966.00 (8/2006-8/2007)

The Juhnke Fund from SDSU Foundation, $10,000.00 (2006)

Research Support Fund, "New Chemopreventive Agents from Marine Sources against Skin Cancer" $7,500.00 (2005-2006)

Research/Scholarship Start-up Funds for New Faculty (2004) $5,000.00




Acitive Research Projects:



Development of novel chemopreventaive agents from marine sources.



Synthesis and evaluation of Corticotropine Releasing Factor (CRF) receptor antagonists as new anti-anxiety agents.



Synthesis and evaluation of antifungal agents.





Synthesis and evaluation of anti-HIV agents.



Professional Activities and Memberships:



American Chemical Society- Medicinal Chemistry

Royal Pharmaceutical Association of Great Britain- The Academy of Pharmaceutical Scientists

The American Association of Colleges of Pharmacy (AACP)

Sigma Xi Research Honor Society (SDSU Chapter)

Rho Chi Honor Society



Collaborations:



2000-present: Specs and Biospecs, The Netherlans

2000-present: National Institute of Allergy and Infectious Disease, Alabama

2000-2002: DuPont Pharmaceuticals, Delaware

1998-present: DowAgraSciences, Indiana

1997-present: National Cancer Institute

1997-1999: DuPont Agricultural Producst, Delaware



000-present:






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