Hesham Fahmy
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Associate Professor of Pharmaceutical Sciences
South Dakota State University
College of Pharmacy
Box 2202C
Brookings SD 57007-0099
Phone: (605) 688-4243
FAX: (605) 688-5993
E-Mail: Hesham.Fahmy@sdstate.edu
B.S. Pharmacy, University of Alexandria
M.S. Pharmaceutical Chemistry, University of Alexandria
Ph.D. Pharmaceutical Chemistry, University of Alexandria
Post-Doctoral: University of Texas
Research Scientist: University of Glasgow, Scotland and the University of Mississippi
Teaching Areas and Courses: Medicinal Chemistry
Medicinal Chemistry I (PHA 340)
Medicinal Chemistry II (PHA 341)
Advanced Medicinal Chemistry (PHA 720)
Topics in Medicinal Chemistry (PHA 725)
Academic/Research Areas:
Novel chemopreventaive agents
Corticotropine Releasing Factor (CRF) receptor antagonists as new anti-anxiety agents
Antifungal Agents
Awards and Honors:
Reviewer for Heteroatom Chemistry
Reviewer for Chemical Papers
Reviewer for Archiv der Pharmazie
Reviewer for European Journal of Medicinal Chemistry
Reviewer for Bio-organic and Medicinal Chemistry Letters
Reviewer for the US Civilian Research and Development Foundation (CRDF)
Patents:
2 USA/International Patents:
Zjawiony, J. K., Fahmy, H., Katsuyama, I., Khalifa, S., Konoshima, T.: Cembranoids of Chemopreventive Activity. PCT Int. Appl. WO 2003095404, A1 20031120 (2003), C.A. 139, 381637 (2003).
Zjawiony, Jordan; Fahmy, Hesham; Stewart, Jeremy; Roth, Bryan. Salvinorin derivatives with selective k-opioid receptor affinity. PCT Int. Appl. WO 2006012643, A2 20060202 (2006), C.A. 144, 164284 (2006).
Publications:
32 publications in national and international journals
Faidallah, H.M., Al-Saadi, M. S., Rostom, S. A. F. and Fahmy, H. Synthesis of some sulfonamides, disubstituted sulfonylureas or thioureas and some structurally related variants. A class of promising antitumor agents: Medicinal Chemistry Research. (2007) Accepted for publication and appeared on the Journal Website
Kundoor, V.,Zhang, X., , Khalifa, S., Bommareddy, A., Khalifa, S., Fahmy, H., Dwivedi, C. Chemopreventive effects of sarcotriol on ultraviolet B-induced skin tumor developments on SKH-1 hairless mice. Marine Drugs, 5, 197-207 (2007)
Zhang, X., Schrader, D., Kundoor, V., Khalifa, S., Zeman, D., Fahmy, H., Dwivedi, C. Effects of Sarcophine-diol in Human Epidermoid Carcinoma A431 Cells and its Possible Mechanism of Action. Cancer Letters, 253, 53-59 (2007).
Rida, S., El-Hawash, S., Fahmy, H., Hazza, A., El-Meligy, M. Synthesis of Novel Benzofuran and Related Benzimidazole Derivative for Evaluation of in vitro Anti-HIV-1, Anticancer, and Antimicrobial Activities. Arch Pharm Res, 29(10), 826-833 (2006).
Kundoor, V., Zhang, X., Khalifa, S., Fahmy, H., Dwivedi, C. A Possible Mechanism of Action of the Chemopreventive Effects of Sarcotriol on Skin Tumor Development in CD-1 Mice. Marine Drugs, 4, 274-285 (2006).
Fahmy, H., Zjawiony, J., Konoshima, K., Tokuda, H., Khan, S., Khalifa, S. Potent Skin Cancer Chemopreventive Activity of Some Novel Semi-synthetic Cembranoids from Marine Sources. Marine Drugs, 4, 28-36 (2006).
Stewart, J., Fahmy, H., Roth, B., Yan, F., Zjawiony, J. Bioisosteric Modification of Salvinorin A, a Potent and Selective Kappa-Opoid Receptor Agonist. Arzneim Forsch./Drug Res. 56(4), 269-275 (2006). Rida, S., El-Hawash, S., Fahmy, H., Hazza, A., El-Meligy, M. Synthesis and in vitro Evaluation of Some Novel Benzofuran Derivatives as Potential Anti-HIV-1, Anticancer and Antimicrobial Agents. Acrch Pharm Res., 29(1), 16-25 (2006). Fahmy, H., Khalifa, S. I., Konoshima, T., Zjawiony, J. K.: An Improved Synthesis of 7,8-Epoxy1,3,11-cembratriene-15R(a), 16-diol, A Cembranoid of Marine Origin With a Potent Cancer Chemopreventive Activity. Marine Drugs, 1, 1-7 (2004). Stewart, J. Katsuyama, I., Fahmy, H., Fronczek, F. R., Zjawiony, J. K.: A Direct Synthesis of 3,5-Dibromo-O-methyl-L-tyrosine. Synthetic Communications 34(3), 531-539 (2004). Bekhit, A. A., Fahmy, H. T., Rostom, S. A., Baraka, A.: Design and Synthesis of Some Substituted 1H-pyrazolyl thiazolo[4,5-d]pyrimidines as Anti-inflammatory - Antimicrobial Agents. Eur. J. Med. Chem. 38(1), 27-36 (2003). Rostom, S. A., Fahmy, H. T., Saudi, M. N.: Synthesis and in-vitro Anti-HIV Screening of Certain 2-(benzoxazol-2-ylamino)-3H-4-oxopyrimidines. Scientia Phatmaceutica, 71(2), 57-74 (2003). Saudi, M. N., Rostom, S. F., Fahmy, H. T., El Ashmaway, I. M.: Synthesis of 2-(4-Biphenylyl)-quinoline-4-carboxylate and carboxamide Analogs. New Human Neurokinin-3 (hNM-3) Receptor Antagonists. Arch. Pham. Pharm. Med. Chem. (Weinheim) 336(3), 165-174 (2003). Fahmy, H. T., Rostom, S. A., Saudi, M. N., Zjawiony, J. K., Robins, D. J.: Synthesis and in-vitro Evaluation of The Anticancer Activity of Novel Fluorinated Thiazolo[4,5-d]pyrimidines. Arch. Pham. Pharm. Med. Chem. (Weinheim) 336(4-5), 216-225 (2003). Bekhit, A., Fahmy, H. T.: Design and Synthesis of Some Substituted 1H-Pyrazolyl-Oxazolidines or 1H-Pyrazolyl-Thiazolidines as Anti-inflammatory-Antimicrobial agents. Arch. Pham. Pharm. Med. Chem. (Weinheim) 336(2), 111-118 (2003). Mahindaratne, M., Fahmy, H., Garcia, J. A., Negrete, G. R.: Synthesese of cis- and trans-7-chloro-7,8,9,10-tetrahydrobenzo[ a]pyren-8-ol: Remarkable Solvent Effect on Epoxide Hydrochlorination Diastereoselectivity. Synthetic Commuincation, 33(8), 1391-1398 (2003). Fahmy, H., Zjawiony, J. K., Khalifa, S., Fronczek, F. R.: A Semi-synthetic Analog of The Cembranoid Sarcophine. Acta Cryst. C59, 85-87 (2003). Katsuyama, I., Fahmy, H., Zjawiony, J. K., Zjaiowny, J. K., Khalifa, S. I., Kilada, R. W, Konoshima, T. , Takasaki, M. and Tokuda, H..: Semisynthesis of New Sarcophine Derivatives With Chemopreventive Activity. J. Natural Products 65, 1808-1814 (2002). Fahmy, H. T., Bekhit, A. A.: Synthesis of Some New Bis-thiazoles As Possible Anticancer Agents. Pharmazie, 57(12), 800-803 (2002). Fahmy, H. T., Rostom, S. A., Bekhit, A. A.: Synthesis and Antitumor Evaluation of New Polysubstituted Thiazole and Derived Thiazolo[4,5-d]pyrimidine Systems. Arch. Pharm. Pharm. Med. Chem. (Weinheim) 335(5), 213-222 (2002). Fahmy, H. T.: Synthesis of Some New Triazoles as Potential Antifungal Agents. Bollitino Chemico Pharmaceutico 140, 423-427 (2001). Fahmy, H. T.: Synthesis and Antimicrobial Screening of Some Novel Thiazoles, Dithiazoles, and Thiazolylpyridines. Pharmazie 52(10), 750-753 (1997). Habib, N. S., Rida, S. M., Badawey, E. A., Fahmy, H. T., Ghozlan, H. A.: Synthesis and Antimicrobial Activity of Rhodanine Derivatives . Eur. J. Med. Chem. 32(9), 759-762 (1997). Habibi, N. S., Rida, S. M., Badawey, E. A., Fahmy, H. T., Ghozlan, H. A.: Synthesis and Biological Investigations of Novel Thiazolyl-benzimidazoles and Benzimidazolyl-thiazlo[4,5-d]pyrimidines. Pharmazie 52(5), 346-350 (1997). Habib, N. S., Rida, S. M., Badawey, E. A., Fahmy, H. T., Ghozlan, H. A.: Synthesis of Novel Thiazolo[4,5-d]pyrimidines Derivatives for Antimicrobial, Anti-HIV, and Anticancer Investigation. Pharmazie 51(12), 927-931 (1996). Habib, N. S., Rida, S. M., Badawey, E. A., Fahmy, H.T.: Condensed Thiazoles:I. Synthesis of 5,7-Disubstituted Thiazolo[4,5-d]pyrimidines as Possible Anti-HIV, Anticancer, and Antimicrobial Agents. Monatsh Chemie 127(11), 1203-1207 (1996). Rida, S. M., Habib, N. S., Badawey, E. A., Fahmy, H. T.: Condensed Thiazoles: II. Synthesis of 7-Substituted Thiazolo[4,5-d]pyrimidines as Possible Anti-HIV, Anticancer, and Antimicrobial Agents. Monatsh Chemie 127(11), 1209-1214 (1996). Mahran, M. A., El-Sayed, O. A., Fahmy, H. T., Ashour, F. A.: Synthesis of Some Novel Perhydrotriazepine-3,6-diones of Potential Antifungal Activity. Alex. J. Pharm. Sci. 10(2), 133-135 (1996). Rida, S. M., Habib, N. S., Badawey, E. A., Fahmy, H. T., Ghozlan, H. A.: Synthesis and Biological Investigations of Some New Thiazolyl-benzimidazoles and Benzimidazolyl-thiazolo[3,2-a]pyridines. Arch. Pharm. (Weinheim) 328(4), 325-328 (1995). Badawey, E. A., Rida, S. M., Hazza, A. A., Fahmy, H. T., Gohar, Y.M.: Potential Antimicrobials I. Synthesis and Structure-Activity Studies of Some New Thiazolo[4,5-d]pyrimidine Derivatives. Eur. J. Med. Chem. 28(2), 91-96 (1993). Badawey, E. A., Rida, S. M., Hazza, A. A., Fahmy, H. T., Gohar, Y.M.: Potential Antimicrobials II. Synthesis and In-Vitro Anti-Microbial Evaluation of Some New Thiazolo[4,5-d]pyrimidine Derivatives. Eur. J. Med. Chem. 28(2), 97-101 (1993). Badawey, Hazza, A. A., E. A., Rida, S. M., Fahmy, H. T.: Assesment of Anti-HIV Activity of Some Benzimidazolyl-thiazoles. Arch. Pharm. (Weinheim) 325(9), 565-567 (1992). Grants:
Grants from The Government of Egypt to support exchange students: $150,000.00 (12/2005-12/2007) Governor's 2010 Individual Research Seed Grant. "Development of potent skin cancer chemopreventive agents from marine sources, $43,966.00 (8/2006-8/2007) The Juhnke Fund from SDSU Foundation, $10,000.00 (2006) Research Support Fund, "New Chemopreventive Agents from Marine Sources against Skin Cancer" $7,500.00 (2005-2006) Research/Scholarship Start-up Funds for New Faculty (2004) $5,000.00
Acitive Research Projects:
Development of novel chemopreventaive agents from marine sources.
Synthesis and evaluation of Corticotropine Releasing Factor (CRF) receptor antagonists as new anti-anxiety agents.
Synthesis and evaluation of antifungal agents.
Synthesis and evaluation of anti-HIV agents.
Professional Activities and Memberships:
American Chemical Society- Medicinal Chemistry
Royal Pharmaceutical Association of Great Britain- The Academy of Pharmaceutical Scientists
The American Association of Colleges of Pharmacy (AACP)
Sigma Xi Research Honor Society (SDSU Chapter)
Rho Chi Honor Society
Collaborations:
2000-present: Specs and Biospecs, The Netherlans
2000-present: National Institute of Allergy and Infectious Disease, Alabama
2000-2002: DuPont Pharmaceuticals, Delaware
1998-present: DowAgraSciences, Indiana
1997-present: National Cancer Institute
1997-1999: DuPont Agricultural Producst, Delaware
000-present:
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