Gudiseva Chandrasekher Ph.D.

Associate Professor of Pharmaceutical Sciences
College of Pharmacy,
South Dakota State University,
Box 2202C
Brookings, SD 57007-1199
Phone 605 688 4090
FAX. 605 688 6232
Email: g.chandrasekher@sdstate.edu

Additional Positions
Adjunct Associate Professor,

Department of Internal Medicine,

Sanford School of Medicine, University of South Dakota

gchandra@usd.edu

Educational Qualifications

Ph.D. Mysore University, India 

MS.  Osmania University, India

Teaching Areas and Courses:

Pharmaceutical Biochemistry (PHA 323)

Pathophysiology (PHA 320)

Field of Research: Ophthalmology 

Area of Research: Cell and Molecular biology - Growth factors and Signal transduction.
Cellular and molecular biology of cornea and lens, the major refractive structures in the anterior chamber of the eye.

Growth factor-mediated signaling mechanisms in corneal injuries and during corneal wound healing

Regulation of cell cycle during lens epithelial cell proliferation and differentiation; and targeting cell cycle machinery for the prevention of posterior capsular opacification (PCO, secondary cataract) development.

Ocular drug delivery.

Professional Services
Member of Association for Research in Vision and Ophthalmology (ARVO)
Reviewer for many  premier scientific journals in biological sciences and
eye research-related journals.

Awards and Grants:

NIH-NEI Grant RO1 EY12701 "Growth Factor Receptor Mediate Signaling Mechanisms in Lens" 2000-05.

University of South Dakota School of Medicine Parsons Research grant, 2006-2007,

University of south Dakota Research Catalyst Grant 2005-2006.

Recent scientific meeting presentations

G. Chandrasekher, G. Maharaj and D. Sailaja. Changes in cell cycle proteins expression during lens epithelial cell proliferation. ARVO Meeting, Fort Lauderdale, Florida, April 2008, Abs #1902.

G. Chandrasekher, D. Sailaja and H. E. P. Bazan. Keratinocyte growth factor (KGF) but not hepatocyte growth factor (HGF) signaling promotes sustained cell survival and long lasting regulation of p21^cip and p27^kip expression in corneal epithelium. ARVO Meeting, Fort Lauderdale, Florida, May 2006.

Publications

1.  G. Chandrasekher and D. Sailaja. Phosphatidylinositol 3-kinase (PI-3K)/Akt but not PI-3K/p70 S6 kinase signaling mediates IGF-1-promoted lens epithelial cell survival. Invest. Ophthalmol. Vis. Sci.  2004, 45, 3577-3588.

2. A. Kakazu, G. Chandrasekher and H.E.P. Bazan. HGF protects corneal epithelial cells from apoptosis by the PI-3K/Akt-1/Bad-, but not ERK1/2-mediated signaling pathway. Invest. Ophthalmol. Vis. Sci. 2004, 45, 2696-2704.

3. G. Chandrasekher and D. Sailaja. Alteration in lens protein tyrosine phosphorylation and phosphatidyl-inositol-3kinase during cataract formation. Curr. Eye Res. 2004, 28, 135-44.

4. G. Chandrasekher and D. Sailaja. Differential activation of phosphatidylinositol 3-kinase signaling during proliferation and differentiation of lens epithelial cells. Invest. Ophthalmol. Vis. Sci.  2003, 44, 4400-11.

5. G. Chandrasekher, X. Ma, T. Lallier and H.E.P. Bazan. Delay of corneal epithelial wound healing and induction of keratocyte apoptosis by platelet activating factor. Invest. Ophthalmol. Vis. Sci. 2002, 43, 1422-1428.