 Assistant Professor of Pharmaceutical Sciences
College of Pharmacy,
South Dakota State University,
Box 2202C
Brookings, SD 57007-1199
Phone 605 688 4090
FAX. 605 688 6232
Email: gareth.davies@sdstate.edu
BSc. (Honors), Biological Sciences, University of Plymouth,
Plymouth, UK.
Ph.D.University of Cardiff, School of Medical and Molecular Bio-Sciences,Cardiff, UK.
Post-Doctoral Appointments: Laboratory of Experimental Immunology, National Cancer Institute; Genetic Therapy Inc. (Novartis); Department of Pediatrics, Medical College of Wisconsin and Children’s Hospital of Wisconsin.
Additional Positions:
Director of Scientific Operations, Avera Institute of Human Behavioral Genetics
Adjunct Assistant Professor, Department of Psychiatry, Sanford School of Medicine, University of South Dakota
Teaching Areas and Courses: Immunology, Molecular Biology/Genetics
Biomedical Science (PHA 324)
Pharmaceutical Biochemistry (PHA 323)
Academic/Research Interests:
Molecular Immunology/Genetics
Transcriptional control of Gene expression in the immune system, HIV pathogenesis, Molecular genetics of Autoimmunity.
Molecular Genetics of Human Behavioral Disorders.
Membership of Professional Societies
American Association of Immunologists
FASEB
American Society for Human Genetics
Journal Review:
Molecular Immunology
Journal of Immunology
Ad hoc reviewer :
Journal of Biological Chemistry
Genes and Immunity
Awards and Grants:
Award for Outstanding Oral presentation; National Cancer Institute
Fellows and Young Investigators Retreat, 2004
Juvenile Diabetes Foundation Post-doctoral Fellowship 2001
Wellcome Trust Research Scholarship 1994-95
Collaborations:
Dr. Timothy Soundy M.D.
Chair, Department of Psychiatry
Sanford School of Medicine,
University of South Dakota
Dr. J.J. Hudziak
Professor, Departments of Psychiatry, Medicine, and Pediatrics
Director of Child and Adolescent Psychiatry
Director of Behavioral Genetics
University of Vermont, College of Medicine
Invited Speaker/Oral Presentations
Annual conference Linking Human Health and Bioscience, Worthington MN, March 28th 2008.
Title :Gene and Environmental Interactions in Childhood Behavioral Disorders.
Voices for Children and South Dakota Mental Health Awareness Advisory Group. November 30th 2007, Chamberlain, South Dakota
Title: How can we use genetics to improve the behavioral health of our children?
Second Annual South Dakota Biotech Summit/Annual Meeting, Sioux Falls, South Dakota, October 18th 2007
Title: Gene and Environmental Interactions in Childhood Behavioral Disorders.
First Annual Conference on Psychiatric Genetics and Genomics, Sioux Falls, South Dakota August 10th and 11th 2007.
Title: An Introduction to Human Behavioral Genetics
Department of Obstetrics and Gynecology, Avera McKennan Hospital Sioux Falls, August 2007
Title: Gene and Environmental Interactions in Childhood Behavioral Disorders.
Clinical First Steps Program, Sanford School of Medicine, University of South Dakota, June 2007.
Title: The Genetics of Multi-factorial Diseases
Keynote address, Golden Key Society Inauguration Ceremony, SDSU 2007
Annual Meeting of the American Association of Immunologists, San Diego 2005.
Title: Identification of a novel KIR promoter that may represent a probabilistic switch.
National Cancer Institute Fellows and Young Investigators Retreat 2005.
Williamsburg, Virginia.
Title : Identification of a novel KIR promoter that may represent a probabilistic switch.
SAIC National Cancer Institute Frederick- Basic Research Program Retreat 2003.
Title :Variegated Gene Expression : Identification of a Programmable Binary Switch.
National Cancer Institute Fellows and Young Investigators Retreat 2004.
Williamsburg, Virginia.
Awarded Prize for outstanding Oral presentation
Title : Playing Dice with NK Cells: Probabilistic Switches Control Ly49 Expression
Publications
Gareth E. Davies, Sarahjane Locke, Jeffrey S. Miller, Charles Lutz and Stephen K. Anderson. (2007) Genes and Immunity. 2007 Apr;8(3):245-53.Identification of probabilistic switches in human KIR genes
Gareth E. Davies*, Ali Saleh, Veronnique Pascal, Paul W Wright, Deborah L. Hodge, Edward H. Cho, Stephen Lockett, Mehrnoosh Abshari, and Stephen K. Anderson (2004) Immunity: Jul;21(1):55-66.
Identification of Probabilistic Transcriptional Switches in the Ly49 Gene Cluster: A Novel Eukaryotic Mechanism for Selective Gene Activation.
* Co- First author
Pascal V, Davies GE, Anderson SK. (2004) Clinical and Investigative Medicine: Vol.27, No 4. A Critical Role for NFkB/p65 in establishing the Ly49 Repertoire of NK cells.
Anderson SK, Pascal, V, Davies GE (2004) Clinical and Investigative Medicine: Vol.27, No 4, 101. A Molecular Explanation for Stochastic Receptor Expression: Probabilistic Switches.
Hessner, M.J., K. Vaughan, L. Meyer, G.E. Davies, S. Nye, X. Wang, S. Ghosh. (2002) Diabetes, Supplement, 51:257. Gene Expression Profiling in the Diabetic Prone (DP) and Diabetic Resistant (DR) BioBreeding Rat.
Davies GE, Sabatakos G, Cryer A, Ramji DP (2000) Biochem. Biophys Res.Commun. May 10; 271(2):346- 352. The Ovine CCAAT-Enhancer Binding Protein delta Gene: Cloning, Characterization, and Species-Specific Autoregulation.
Sabatakos G, Davies GE, Grosse M, Cryer A, Ramji DP (1998)
Biochem. J. Aug 15; 334 (Pt.1) 205-210. Expression of the genes encoding the CCAAT-enhancer binding protein isoforms in the mouse mammary gland during lactation and involution.
Database SubmissionDavies, G. E., Sabatakos, G., Cryer, A. and Ramji, D. P. (2000) Ovis aries C/EBP delta gene for CCAAT/enhancer binding protein delta. EMBL/GenBank/DDBJ Accession number AJ276820.
Meeting Abstracts
A Method for Obtaining High Quality Human Genomic DNA
from 11-year-old Cotton Spit Wads for Genetic Studies of Behavioral Disorders
Erik A. Ehli, R.N., M.S., Timea Lengyel-Nelson, M.S.,
James Hudziak, M.D. & Gareth E. Davies, Ph.D.
Behavioral Genetics Association Conference 2008, June 25th-28th Louisville, KY
Val/Val is Associated with Current Conduct Disorder Symptoms but Not Other Externalizing Behavior in Children with ADHD.
Lynsay Ayer, B.A., Robert Althoff, M.D., Ph.D., Timea Nelson, M.S., Erik Ehli, R.N.,M.S., Gareth E. Davies, Ph.D. & James Hudziak, M.D.,
Behavioral Genetics Association Conference 2008, June 25th-28th Louisville, KY
Genetic Differences in Childhood Disorders of Self-Regulation.
Robert Althoff, M.D., Ph.D., Lynsay Ayer, B.A., Timea Nelson, M.S., Erik Ehli, R.N., M.S., Gareth E. Davies, Ph.D. & James Hudziak, M.D.,
Behavioral Genetics Association Conference 2008, June 25th-28th Louisville, KY
Paternal Differences in Parenting Based on offspring COMT Genotype.
David C. Rettew, M,D., Lynsay Ayer, B.A., Robert Althoff, M.D., Ph.D., Timea Nelson, M.S., Erik Ehli, R.N., M.S., Gareth Davies, Ph.D. & James Hudziak, M.D.,
Behavioral Genetics Association Conference 2008, June 25th-28th Louisville, KY
Stephen K. Anderson Gareth E. Davies, Sarahjane M. Locke, Paul W. Wright,
Rebecca J.Hanson, and Jeffrey S. Miller.
Identification of probabilistic switches in the human KIR genes
Annual Meeting of the American Association of Immunologists, Boston 2006
Gareth E. Davies, Sarahjane Locke, Jeffrey S. Miller and Stephen K. Anderson.
Identification of a novel KIR promoter that may represent a probabilistic switch
5th Annual Conference of FOCIS. San Francisco, 2006.
Obrad Kokanovic, Gareth E. Davies, Takaya Oda, Shahnaz Kazi Xuijing Wang, , Sun-Wei Guo, Settara C. Chandrasekharappa, Soumitra Ghosh. A Single nucleotide polymorphism in the Delta1 gene mapped to IDDM8 is associated with Type I Diabetes Mellitus.
10th International Congress of Human Genetics, Vienna, 2001.
Obrad Kokanovic, Gareth E. Davies, Takaya Oda, Shahnaz Kazi, Sash Lopaticki Xuijing Wang, Huoy-Jii Khoo, Sun-Wei Guo, Grant Morahan, Settara C. Chandrasekharappa, Soumitra Ghosh
A Single nucleotide polymorphism in the Delta1 gene mapped to IDDM8 is associated but not linked to Type I Diabetes Mellitus.
American Diabetes Association, 61st Scientific Sessions, Philadelphia, 2001.
Gareth E. Davies, Kiran Sakhuja, Scott Pattison, Michael Kaleko, Sheila Connelly.
Evaluation of Glucagon-Like Peptide 1 (GLP-1) as a Therapeutic Transgene for Gutless Adenoviral Vector-Mediated Gene Therapy of Type 2 Diabetes
5th Annual Meeting of the American Society of Gene Therapy, Boston, 2002.
Martin Hessner, Steven Nye, Kimberley Vaughan, Lisa Meyer, Gareth Davies, Xujing Wang, Soumitra Ghosh. Gene Expression Profiling in the Diabetic Prone (DP) and Diabetic Resistant (DR) Biobreeding Rat.
American Diabetes Association, 62nd Scientific Sessions, San Francisco, 2002.
Gareth E. Davies , Ali Saleh, Deborah L. Hodge, Mehrnoosh Abshari,
and Stephen K. Anderson.
Variegated Gene Expression : Identification of a Programmable Binary Switch
SAIC National Cancer Institute Frederick- Basic Research Program Retreat 2003
Gareth E. Davies, Veronnique Pascal ,Ali Saleh, Paul W Wright, Deborah L. Hodge, Mehrnoosh Abshari, and Stephen K. Anderson.
Variegated Gene Expression : Identification of a Programmable Binary Switch.
National Cancer Institute Fellows and Young Investigators Retreat 2004
Stephen K Anderson, Veronique Pascal and Gareth E Davies.
A Molecular Explanation for Stochastic Receptor Expression: Probabilistic Promoter Switches.
12th International Congress of Immunology and 4th Annual Conference of FOCIS. Montreal 2004.
Véronique Pascal, Gareth E. Davies, Paul W. Wright and Stephen K. Anderson
A Critical Role for NFkB/p65 in establishing the Ly49 Repertoire of NK cells
12th International Congress of Immunology and 4th Annual Conference of FOCIS. Montreal 2004.
Stephen K Anderson, Veronique Pascal and Gareth E Davies.
A Molecular Explanation for Stochastic Receptor Expression: Probabilistic Promoter Switches.
Natural Killer Cell meeting, Amsterdam 2004.
Véronique Pascal, Gareth E. Davies, Paul W. Wright and Stephen K. Anderson
A Critical Role for NFkB/p65 in establishing the Ly49 Repertoire of NK cells.
Natural Killer Cell meeting, Amsterdam 2004
Gareth E. Davies, Sarahjane Locke, Jeffrey S. Miller and Stephen K. Anderson.
Identification of a novel KIR promoter that may represent a probabilistic switch.
Annual Meeting of the American Association of Immunologists, San Diego 2005.
Personal Interests:
Music:
Jazz: Miles Davis, John Coltrane, Sonny Rollins.
Bob Dylan,
The Band,
The Grateful Dead
Literature:
Jack Kerouac, and The Beat Generation,
The Philosophy and History of Science,
Buddhism
Vegetarianism
Running
Travel
The outdoors
My Family
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