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Brian Logue, Research Assistant Professor
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Contact Info
Phone: 605-688-6698
Fax: 605-688-6364
E-mail: Brian.Logue@sdstate.edu
Dr. Logue's home page
Education
B.S., 1995, South Dakota State University
Ph.D., 2000, Oregon State University
Research Appointment
U.S. Army Medical Research Institute of
Chemical Defense, 2002-2004
External Funding
DOA
The overarching theme of my research is development of chemical and biological sensors for environmental analytical and bioanalytical applications. My research focuses on the detection of environmental contaminants and the detection of chemical and biological warfare (CBW) agents via their chemical or biological signatures. Wherever practical, nanoscale technology is used to address these problems. Cur-rent and future projects include research in CBW agent detection, environmental contaminant sensing, and the use of nanotechnology for sensing.
Past exposure to cyanide is difficult to determine because of the ubiquitous nature of cyanide in the body and the difficulty in measuring cyanide directly because of its nucleophilic properties and volatile nature. Therefore, new metabolites must be elucidated and methods developed to analyze those metabolites. One current project focuses on analysis of a cyanide chemical warfare agent metabolite in blood and urine for verification of past exposure to cyanide by detection of this metabolite. This metabolite is very promising and may even contribute to the toxicity of cyanide in the human body. Another difficulty in determining past exposure to CBW agents in biological matrices is that the “window of detection” of most chemical agents is very short. In the human body, the upper residence time for metabolites of most chemical agents is approximately five days. To address this problem, research in the discovery of metabolites with longer residence times can be pursued. Alternatively, a matrix that stores and protects these metabolites would allow a longer window of detection. Hair has shown great promise in its ability to address this problem as metabolites get trapped in the hair matrix and are protected from degradation. Preliminary work in our lab indicates that metabolites of sulfur mustard can be determined in hair matrices of sulfur mustard exposed pigs. This indicates that we may be able to lengthen the window of detection of chemical warfare agent exposure from a week up to a maximum of a year.
An important component of protecting human health and the natural environment is assessment of potential exposure to humans and ecosystems to harmful contaminants. Multi-residue techniques reduce time, effort, and costs of environmental assessment of a particular area by analyzing for multiple contaminants with one analytical method. Therefore, we are developing a technique similar to solid-phase microextraction for the analysis of multiple residues of harmful environmental contaminants that may translate into more sensitive, effective, and efficient assessment of potential exposure of humans and the ecosystem to harmful contaminants.
In light of recent events, our research in the field of chemical and biological warfare (or terrorism) detection, as well as research in nanotechnology, is very timely and exciting. Our research is directly applicable to the welfare of human beings and the environment that we live in, making this work relevant our own lives in the 21st century.
Publications
Logue B.A., Kirschten N.P., Moser M.A., Petrikovics I., Rockwood G.A., and Baskin S.I. (2005) Determination of the cyanide metabolite 2-aminothiazoline-4-carboxylic acid in urine and plasma by gas chromatography-mass spectrometry. Journal of Chromatography B, In Press.
Logue B.A., Smith R. W., and Westall J.C. (2004) Role of Surface Alternation in Determining the Mobility of U(VI) in the Presence of Citrate: Implications for Extraction of U(VI) from Soils. Environ-mental Science and Technology 38(13), 3752-3759.
Baskin S.I., Petrikovics I., Kurche J.S., Nicholson J.D., Logue B.A., Maliner B.J., and Rockwood G.A. (2004) Insights on Cyanide Toxicity and Methods of Treatment. In: Pharmacological Perspectives of Toxic Chemicals and Their Antidotes, Eds: Flora, S.J.S., Romano, J.A. Jr., Baskin, S.I., Sekhar K., Narosa Publishing House, New Delhi, India, 2004.
Logue B.A., Smith R.W., and Westall J.C. (2004) U(VI) Adsorption of Natural Iron-Coated Silica Sands: Comparison of Surface Complexation Modeling Approaches to Modeling Adsorption on Heterogeneous Environmental Materials. Applied Geochemistry 19 (12), 1937-1951.
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