 |
Dr. Fathi Halaweish, Assistant Professor
|
Phone: (605) 688-4269
Fax: (605) 688-6364
E mail Dr. Fathi Halaweish
Dr. Halaweish's home page
Education
• B.Pharm, 1976; MS (Natural Products) 1981
University of Mansoura, Egypt
• Ph.D.,1987 (Pharmaceutical Chemistry and Pharmacognosy), University of Wales, Cardiff, U.K.
Postdoctoral Appointments
University of Delaware
External Funding
USDA
My research interests are focused on the chemistry, metabolism, synthesis, tissue culture production of the biologically active organic natural products and its utilization as pharmaceutical and agrochemical agents. The high degree of biodiversity of plants represents a wealth of novel organic natural com pounds to be explored. Our objective is to isolate active components from plant extracts which shows potential activity [such as antitumor and antiviral] through bioassay guided fractionation. I am currently studying acetogenins which have a potent cytotoxic, a potent antitumor against ovarian, leukemia and prostate cancer. Ribosome inactivating proteins (RIP) from cucurbits [a potential anti-tumor and anti-AID agents] is another research program I am pursuing it. Native American medicine is another objectives of my research to evaluate their potential activities and toxicity.
Once active compounds are isolated using preparative HPLC, their structures are solved using various NMR experiments, MS, LC-MS, GC-MS, UV and IR. For compounds that seem particularly promising we then explore methods to prepare them by tissue culture or synthesis and/or semi-synthesis.
Another research interest of my program is plant-animal and plant insect biochemical interactions, and environmental effects [such as ozone depletion & UV-B] on biosystems.
Publications
Afifi, M.S.; Ross, S.A.; ElSohly, M.A.; Neim, Z.E.; Halaweish, F.T., 1999, Cucurbitacins of cucumis prophetarum and cucumic prophetarum justl., J. Chem. Ecol., 25, 847-859.
Halaweish, F.T.; Tallamy, D.W., 1998, Production of cucurbitacins by cucurbit cell cultures, Plant Science, 131, 209-218.
Halaweish, F.T.; Tallamy, D.W., 1993, Quantitative determination of cucurbitacins by high perfor-mance liquid chromatography and high performance thin layer chromatography, J. Liq. Chromatog. 16, 491-511.
Halaweish, F.T., 1993, Cucurbitacins from cucurbita texana: Evidence for the role of isocucurbitacins, J. Chem. Ecol., 19, 29-37.
Halaweish, F.T.; Tallamy, D.W., 1993, A new cucurbitacins profile for cucurbita andreana: A candidate for cucurbitacins tissue culture, J. Chem. Ecol., 19, 1133-1139.
Tallamy, D.W. and Halaweish, F.T., 1993, The effects of age, reproductive activity, sex and prior exposure on sensitivity to cucurbitacins in Southern root worm (coleoptera: chrysomelidae)., Physiol. Chem. Ecol., 22 (10), 925-932.
EI-Sharkawy, S.; Selim; Halaweish, F.T., 1991, Microbial transformation of zearalenone to zearalenone sulphate, Appl. Environ. Microbio., Feb., 549-552.
Halaweish, F.T.; Dougall. D., 1990, Sinapoyl glucose synthesis by extracts of wild carrot cells cultures, Plant Science, 71, 179-184. |
|
