Professor
Email: Jane.Hennings@sdstate.edu
Phone: 605-688-5171
Fax: 605-688-6003

Education:
BS, Natural Resources Management, University of Wisconsin-Madison, 1975
DVM, Veterinary Medicine, University of Minnesota-St. Paul, 1983
MS, Veterinary Science, University of Wisconsin-Madison, 1990
Postdoctoral Research Associate, Veterinary Science, South Dakota State University, 1996

Specialty/Certification:
Veterinary Microbiology/Virology

Professional Emphasis:
Porcine Reproductive and Respiratory Virus, Johne's Disease (Mycobacterium paratuberculosis) in cattle, Polymerase Chain Reaction (PCR) diagnostics, Section Leader for Animal Disease Research and Diagnostic Laboratory Molecular Diagnostic Section.


Grants Funded (last 5 years)

Christopher-Hennings J., Acquisition of the Bio-Plex suspension Array system for multiplex assay development in swine research.  Mucosal immunity to porcine reproductive and respiratory syndrome virus in the boar reproductive tract.  USDA-NRI Equipment Grant, $28,000 requested (match for total of $56,000 instrument).

Faaberg K., J. Christopher-Hennings, J. Collins, E. Retzel.  Implementation of a PRRSV database-Renewal.  National Pork Board $51,157. 2006. 

Christopher-Hennings J.  C. Munoz-Zanzi, N. Loskutoff, J. Lunney, E. Nelson.  PRRSV surveillance, elimination and immunity in boars and boar semen.  USDA-NRI Integrated Program, $130,201.  April 2006-May 2007.

Nelson E.A., R.R.R. Rowland, J. Christopher-Hennings.  Emerging European-like PRRSV in the U.S.:  Implications for diagnostic and control strategies.  National Pork Board.  Jan 2005-Jan 2006, $119,380.

Fang Y., D Benfield, R. R. R. Rowland, J. Christopher-Hennings, E.A. Nelson.  Accurate ELISA test development for PRRSV serology:  evaluation of cysteine protease domains of nsp2 as potential diagnostic targets.  National Pork Board, Aug 2005-Aug 2006, $46,000.

Wang X, W. Cafruny, Y. Fang, R. Kaushik, J. Christopher-Hennings, E.A. Nelson.  Improved diagnostic and vaccination strategies for PRRSV.  SD 2010 Program (CIDRV), Oct 2004-Oct 2006, $100,000.

Rowland, R.R., J. Zimmerman, R. Evans, J. Christopher-Hennings, E.A. Nelson and D.A. Benfield.  Management of PRRS Persistence:  Identification of persistently infected swine.  USDA-NRI Integrated Program.  Sept. 2004 to Sept. 2005.  $314,507.

Wang, X., W. Bowers, E.A. Nelson and J. Christopher-Hennings.  A Novel herpesvirus vector approach for PRRSV vaccines. National Pork Board.  Sept. 2004 to Sept. 2005. $25,000.

Murtaugh et. al. Integrated control and elimination of porcine reproductive and respiratory syndrome virus (PRRSV) in the U.S.  USDA-NRI Integrated Program.  March 2004-Dec 2007 $4,400,000.  (PRRS Integrated program funding distributed on a competitive basis –including funded Integrated subawards as indicated above).

Christopher-Hennings J., E. A. Nelson.  2002-2004.  Porcine Reproductive and Respiratory Syndrome Virus detection, protection and elimination of virus.  Agriculture Experiment Station.  $6,000.

Christopher-Hennings J.  E. A. Nelson.  Detection, Predictors, Immune Mechanisms and Prevalence of PRRSV Persistence in Boars.  Iowa Pork Producers Council.  2002.  $42,000.

Christopher-Hennings J.  E. A. Nelson.  Development and validation of a real-time, quantitative PCR for the detection of PRRSV in boar semen and serum.  PIC, Boehringer-Ingelheim Vetmedica, Tetracore, Inc.  2002-2003. $42,123.

Christopher-Hennings J, E.A. Nelson, B. Epperson, C. Chase, D. Henning.  Johne’s Disease in Cattle and Buffalo:  A South Dakota Concern.  Agricultural Experiment Station Cooperative Grants Program.  2000-2002.  $45,000. 

Publications (last 5 years)

Wang X., M. Eaton, M. Mayer, H. Li, D. He,  E.Nelson, J. Christopher-Hennings.  2007.  Porcine reproductive and respiratory syndrome virus productively infects monocyte-derived dendritic cells and compromises their antigen-presenting ability.  Archives of Virology 152:289-303.

Fang Y., R. R. R. Rowland, M. Roof, J. K. Lunney, J. Christopher-Hennings, E. A. Nelson.  2006.  A full-length cDNA infectious clone of North American Type 1 porcine reproductive and respiratory syndrome virus:expression of green fluorescent protein in the Nsp2 region.  Journal of Virology 80:11447-11455.

Christopher-Hennings, J., M. Dammen, E. Nelson, R. Rowland, R. Oberst. 2006.  Comparison of RNA extraction methods for the detection of porcine reproductive and respiratory syndrome virus from boar semen.  Journal of Virological Methods 136:248-253. 

Wu W.-H., Y. Fang, R. R. R. Rowland, S.R. Lawson, J. Christopher-Hennings, K.-J. Yoon E.A. Nelson.  2005.  The 2b protein as a minor structural component of PRRSV.  Virus Research 114:177-181.

Wasilk, A., J. Callahan, J. Christopher-Hennings, B.T. Gay, Y. Fang, M. Dammen, M. Torremorell, D. Polson, M. Mellencamp, E.A. Nelson and W. Nelson.  2004.  Detection of U.S. and Lelystad/European-like porcine reproductive and respiratory syndrome virus and relative quantitation in boar semen and serum by real-time PCR J. Clin. Micro.42 (10):4453-4461.

Zimmerman J, D. Benfield, J. Christopher-Hennings, S. Dee, G. Stevenson.  June, 2004.  Porcine reproductive and respiratory syndrome.  Proceedings PORK Academy sponsored by the Pork Checkoff and Pfizer Animal Health.  Des Moines, Iowa (compact disc - 11 pages).

Fang, Y., D.-Y. Kim, S. Ropp, P. Steen, J. Christopher-Hennings, E.A. Nelson and R.R.R. Rowland. 2004.  Heterogeneity in Nsp2 of European-like porcine reproductive and respiratory syndrome viruses isolated in the United States.  Virus Research 100:229-235.

Ropp, S.L., C.E. Mahlum-Wees, Y.Fang, E.A. Nelson, K.D. Rossow, M. Bien, B. Arndt, S. Preszler, P. Steen, J. Christopher-Hennings, J.E. Collins, D.A. Benfield and K.S. Faaberg.  Characterization of emerging European-like PRRSV isolates in the United States. Journal of Virology 78:3684-3703.

J. Christopher-Hennings, M. A. Dammen, S. Weeks, W. B. Epperson, S. N. Singh, G. L. Steinlicht, Y. Fang, J. L. Skaare, J. L. Larsen, J. B. Payeur, E. A. Nelson.  2003.  Comparison of two DNA extractions and nested PCR, real-time PCR, a new commercial PCR assay and bacterial culture for detection of Mycobacterium avium subsp. paratuberculosis in bovine feces.  Journal of Veterinary Diagnostic Investigation 15:87-93.

Kuckleburg, C. J. , C. C. Chase, E. A. Nelson, S. A. Marras, M. A. Dammen,

J. Christopher-Hennings.  2003.  Detection of bovine leukemia virus in blood and milk by nested and real-time polymerase chain reaction.  Journal of Veterinary Diagnostic Investigation 15:69-74.

Fang, Y, W-H Wu, J. L. Pepper, J. L. Larsen, S. A. E. Marras, E. A. Nelson, W. B. Epperson, J. Christopher-Hennings.  2002.  Comparison of real-time, quantitative PCR using molecular beacons to nested PCR and culture methods for the detection of Mycobacterium avium (subspecies paratuberculosis) in bovine fecal samples.  Journal of Clinical Microbiology 40:287-291.

Benson  J. E., M. J. Yaeger, J. Christopher-Hennings, K. Lager, K-J Yoon.  2002.  A comparison of virus isolation, immunohistochemistry, fetal serology, and reverse-transcription polymerase chain reaction assay for the identification of porcine reproductive and respiratory syndrome virus transplacental infection in the fetus.  Journal of Veterinary Diagnostic Investigation 14:8-14.

Christopher-Hennings, J., K.S. Faaberg, W.L. Mengeling, M.P. Murtaugh, E.A. Nelson, M.B. Roof, E.M. Vaughn, K.-J. Yoon and J.J. Zimmerman.  2002.  PRRS diagnostic: Interpretation and limitations.  Swine Health and Production 10:213-218.